Royal Air Force Typhoon FGR4s have operated alongside France's air force in a coordinated attack targeting an hidden munitions depot in Syria used by the Daesh militant organization, according to the UK's MoD.
The facility, located using reconnaissance, was believed to be housing weapons and explosive materials, the release indicated, and was situated in hills just to the north of the historic site of Palmyra in Syria's central region.
"Our aircraft utilized precision-guided Paveway IV munitions to hit a number of access tunnels providing entry to the site... preliminary assessments are that the target was engaged successfully," the MoD said.
There was no evidence of any harm to civilians in the attack on Saturday evening and all the aircraft made a safe return, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager refuelling tanker.
The Islamic State group - also known as the so-called Islamic State - established militant control over significant areas in Syria and Iraq until 2019.
"This strike shows British leadership, and commitment to operate in unison with our allies, to eradicate any revival of the terrorist group and their harmful and extremist ideologies in the region," UK Defence Secretary the minister stated.
RAF aircraft have carried out surveillance missions over Syrian airspace to "deter any attempted comeback" of Islamic State after its routing at the Baghuz confrontation in 2019, the authorities noted.
"I extend gratitude to all the members of our armed forces participating in this mission for their expertise and their bravery," the Defence Secretary said. "Including them were a great many British troops deployed over the holidays. This mission, to eliminate militants who endanger our security, highlights how UK forces are prepared to act, continuously, ensuring Britain's security at home and powerful internationally."
During December, the American forces executed what it termed a "large-scale strike" targeting IS targets in the country, after an ambush killed two US servicemembers and a local interpreter in the Palmyra area.
The United Nations says IS still has roughly 5-7 thousand combatants in Iraq and Syria.